Visn. Nac. Akad. Nauk Ukr. 2014. (1): 80—88

S.I. Romanyuk, S.V. Komisarenko
Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, Kyiv


The Nobel Prize in Physiology and Medicine 2013 was awarded to James E. Rothman, Randy W. Schekman, and Thomas C. Südhof with Nobel Committee motivation: “for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells”.

Keywordsvesicle traffic, Nobel Prize, J. Rothman, R. Schekman, T. Südhof.


Language of article: ukrainian.


  1. Press Release Nobel Committee.
  2. Novick P., Field C., Schekman R. Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell. 1980. 21(1): 205–15.
  3. Block M.R., Glick B.S., Wilcox C.A. et al. Purification of an N-ethylmaleimide-sensitive protein catalyzing vesicular transport. PNAS. 1988. 85(21): 7852–56.
  4. Weidman P.J., Melançon P., Block M.R., Rothman J.E. Binding of an N-ethylmaleimide-sensitive fusion protein to Golgi membranes requires both a soluble protein(s) and an integral membrane receptor. J. Cell. Biol. 1989. 108(5): 1589–96.
  5. Oyler G.A., Higgins G.A., Hart R.A., Battenberg E., Billingsley M., Bloom F.E., Wilson M.C. The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations. J. Cell. Biol. 1989. 109(6): 3039–52.
  6. Inoue A., Obata K., Akagawa K. Cloning and sequence analysis of cDNA for a neuronal cell membrane antigen, HPC-1 (syntaxin 1). J. Biol. Chem. 1992. 267(15): 10613–19.
  7. Trimble W.S., Cowan D.M., Scheller R.H. VAMP-1: a synaptic vesicle-associated integral membrane protein. PNAS. 1988. 85(12): 4538–42.
  8. Söllner T., Whiteheart S.W., Brunner M., Erdjument-Bromage H., Geromanos S., Tempst P., Rothman J.E. SNAP receptors implicated in vesicle targeting and fusion. Nature. 1993. 362(6418): 318–24.
  9. Gao Y., Zorman S., Gundersen G., Xi Z., Ma L., Sirinakis G., Rothman J.E., Zhang Y. Single reconstituted neuronal SNARE complexes zipper in three distinct stages. Science. 2012. 337(6100): 1340–43.
  10. Brose N., Petrenko A.G., Südhof T.C., Jahn R. Synaptotagmin: a calcium sensor on the synaptic vesicle surface. Science. 1992. 256(5059): 1021–25.
  11. Hata Y., Slaughter C.A., Südhof T.C. Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature. 1993. 366(6453): 347–51.
  12. McMahon H.T., Missler M., Li C., Südhof T.C. Complexins: cytosolic proteins that regulate SNAP receptor function. Cell. 1995. 83(1): 111–19.
  13. Maximov A., Tang J., Yang X., Pang Z.P., Südhof T.C. Complexin controls the force transfer from SNARE complexes to membranes in fusion. Science. 2009. 323(5913): 516–21.
  14. Wang Y., Okamoto M., Schmitz F., Hofmann K., Südhof T.C. Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion. Nature. 1997. 388(6642): 593–98.
  15. Zhou P., Bacaj T., Yang X. et al. Lipid-Anchored SNAREs Lacking Transmembrane Regions Fully Support Membrane Fusion during Neurotransmitter Release. Neuron. 2013. 80(2): 470–83.
  16. Südhof T.C. Neurotransmitter release: the last millisecond in the life of a synaptic vesicle. Neuron. 2013. 80(3): 675–90. http:/
  17. Zierath J.R., Lendahl U. Machinery regulating vesicle traffic, a major transport system in our cells.
  18. Lashuel H.A, Hirling H. Rescuing defective vesicular trafficking protects against alpha-synuclein toxicity in cellular and animal models of Parkinson's disease. ACS Chem. Biol. 2006. 1(7): 420–24.
  19. Alter S.P., Lenzi G.M., Bernstein A.I., Miller G.W. Vesicular integrity in Parkinson's disease. Curr. Neurol. Neurosci. Rep. 2013. 13(7): 362.
  20. Suzuki T., Araki Y., Yamamoto T., Nakaya T. Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis. J. Biochem. 2006. 139(6): 949–55.
  21. Caviston J.P., Holzbaur E.L. Huntingtin as an essential integrator of intracellular vesicular trafficking // Trends Cell Biol. – 2009. – V. 19, N 4. – P. 147–155.
  22. Krzewski K., Cullinane A.R. Evidence for defective Rab GTPase-dependent cargo traffic in immune disorders. Exp. Cell. Res. 2013. 319(15): 2360–67.
  23. Ge J., Shao F. Manipulation of host vesicular trafficking and innate immune defence by Legionella Dot/Icm effectors. Cell Microbiol. 2011. 13(12): 1870–80.
  24. Rossetto O., de Bernard M., Pellizzari R., Vitale G., Caccin P., Schiavo G., Montecucco C. Bacterial toxins with intracellular protease activity. Clin. Chim. Acta. 2000. 291(2): 189–99.
  25. Blasi J., Chapman E.R., Link E., Binz T., Yamasaki S., De Camilli P., Südhof T.C., Niemann H., Jahn R. Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25. Nature. 1993. 365(6442): 160–63.