Visn. Nac. Akad. Nauk Ukr. 2016. (7): 27-42

I.M. Trakhtenberg 1, E.L. Levytsky 2

1 Institute of Occupational Medicine of National Academy of Medical Sciences of Ukraine, Kyiv
2 Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, Kyiv


The review provides basic information on the structural and functional organization of nuclear chromatin, which is the target of genotoxic action of potentially dangerous chemicals to humans, such as organic solvents, pesticides and industrial poisons. For example of these toxic substances the molecular mechanisms of their genotoxic action were examined. Particular attention is paid to the mechanisms of free radical toxic destruction of nuclear genome under the influence of dangerous chemicals. The conclusion is made about the special role of DNA and histone proteins in nuclear chromatin mechanisms of genotoxicity development and the repair processes of these basic structures and appropriateness of the use of antioxidants-genoprotectors as the means of pharmacological protection of nuclear genome in conditions of chemical damage.
Keywords: nuclear chromatin, genotoxic substances, chemical damage, antioxidants, genoprotector.

Language of article: ukrainian


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