Visn. Nac. Akad. Nauk Ukr. 2017. (12): 28-34

Yu.V. Malyukin
Institute for Scintillation Materials of National Academy of Sciences of Ukraine, Kharkiv

According to the materials of scientific report at the meeting of the Presidium of NAS of Ukraine, October 11, 2017

The report presents the results of investigations of the luminescence properties of a new class of nano-materials — polyfunctional redox-active nanocrystals that can simultaneously take an active part in biological processes occurring at the level of individual cells and are characterized by the presence of their own luminescence, the intensity of which correlates with the pro-/antioxidant activity of nanoparticles. As the most promising redox-active nanomaterials, cerium dioxide nanocrystals (CeO2-x) and orthovanadates of RE elements (ReVO4:Eu3+) are analyzed. Studies carried out with the help of stationary and time-resolved spectroscopy methods involving controlled change of redox-status of NPs surrounding, show that they can both directly demonstrate the anti-/prooxidant effect, and act as an intermediate in the processes of generation of singlet oxygen by photosensitizer molecules. The prospect of using nanocrystals for a range of biomedical applications as materials for the needs of photodynamic therapy and biological antioxidants is shown.
Keywords: nanocrystals, antioxidants, photodynamic therapy.

 Language of article: ukrainian



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