Visn. Nac. Akad. Nauk Ukr. 2017. (12): 50-62 

S.I. Romanyuk, S.V. Komisarenko
Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, Kyiv

Nobel Prize in Physiology or Medicine for 2017

On October 2, the Nobel Committee at the Karolinska Institute announced the names of the winners of the Nobel Prize in Physiology or Medicine for 2017. These were three scientists from the United States: Jeffrey C. Hall, Michael Rosbash and Michael W. Young. The award was given to them “for the discovery of the molecular mechanisms controlling the circadian rhythm.”

 Language of article: ukrainian



1.     The 2017 Clarivate Citation Laureates.

2.     The Nobel Prize in Physiology or Medicine 2017. Press Release.

3.     Circadian rhythm. From Wikipedia.

4.     Circadian rhythmЦиркадный_ритм

5.     Sulzman F.M., Ellman D., Fuller C.A., Moore-Ede M.C., Wassmer G. Neurospora circadian rhythms in space: a reexamination of the endogenous-exogenous question. Science. 1984. 225: 232.

6.     Halberg F. Chronobiology. Annu. Rev. Physiol. 1969. 31: 675.

7.     Konopka R.J., Benzer S. Clock mutants of Drosophila melanogaster. Proc. Nat. Acad. Sci. USA. 1971. 68(9): 2112.

8.     Reddy P., Zehring W.A., Wheeler D.A., Pirrotta V., Hadfield C., Hall J.C., Rosbash M. Molecular analysis of the period locus in Drosophila melanogaster and identification of a transcript involved in biological rhythms. Cell. 1984. 38(3): 701.

9.     Bargiello T.A., Jackson F.R., Young M.W. Restoration of circadian behavioral rhythms by gene transfer in Drosophila. Nature. 1984. 312(5996): 752.

10. Zehring W.A., Wheeler D.A., Reddy P., Konopka R.J., Kyriacou C.P., Rosbash M., Hall J.C. P-element transformation with period locus DNA restores rhythmicity to mutant, arrhythmic Drosophila melanogaster. Cell. 1984. 39(2): 369.

11. Hardin P.E., Hall J.C., Rosbash M. Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels. Nature. 1990. 343(6258): 536.

12. Liu X., Zwiebel L.J., Hinton D., Benzer S., Hall J.C., Rosbash M.J. The period gene encodes a predominantly nuclear protein in adult Drosophila. Neuroscience. 1992. 12(7): 2735.

13. Sehgal A., Price J.L., Man B., Young M.W. Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless. Science. 1994. 263(5153): 1603.

14. Gekakis N., Saez L., Delahaye-Brown A.M., Myers M.P., Sehgal A., Young M.W., Weitz C.J. Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL. Science. 1995. 270(5237): 811.

15. Myers M.P., Wager-Smith K., Rothenfluh-Hilfiker A., Young M.W. Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock. Science. 1996. 271(5256): 1736.

16. Allada R., White N.E., So W.V., Hall J.C., Rosbash M. A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Cell. 1998. 93(5): 791.

17. Rutila J.E., Suri V., Le M., So W.V., Rosbash M., Hall J.C. CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless. Cell. 1998. 93(5): 805.

18. King D.P., Zhao Y., Sangoram A.M., Wilsbacher L.D., Tanaka M., Antoch M.P., Steeves T.D., Vitaterna M.H., Kornhauser J.M., Lowrey P.L., Turek F.W., Takahashi J.S. Positional cloning of the mouse circadian clock gene. Cell. 1997. 89(4): 641.

19. Hao H., Allen D.L., Hardin P.E. A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila melanogaster. Mol. Cell Biol. 1997. 17(7): 3687.

20. Ephrussi A., Church G.M., Tonegawa S., Gilbert W. B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo. Science. 1985. 227(4683): 134.

21. Emery P., So W.V., Kaneko M., Hall J.C., Rosbash M. CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity. Cell. 1998. 95(5): 669.

22. Ceriani M.F., Darlington T.K., Staknis D., Mаs P., Petti A.A., Weitz C.J., Kay S.A. Light-dependent sequestration of TIMELESS by CRYPTOCHROME. Science. 1999. 285(5427): 553.

23. Qin S., Yin H., Yang C., Dou Y., Liu Z., Zhang P., Yu H., Huang Y., Feng J., Hao J., Hao J., Deng L., Yan X., Dong X., Zhao Z., Jiang T., Wang H.W., Luo S.J., Xie C. A magnetic protein biocompass. Nat. Mater. 2016. 15(2): 217.

24. Price J.L., Blau J., Rothenfluh A., Abodeely M., Kloss B., Young M.W. Double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Cell. 1998. 94(1): 83.

25. Martinek S., Inonog S., Manoukian A.S., Young M.W. A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock. Cell. 2001. 105(6): 769.

26. Lin J.M., Kilman V.L., Keegan K., Paddock B., Emery-Le M., Rosbash M., Allada R. A role for casein kinase 2alpha in the Drosophila circadian clock. Nature. 2002. 420(6917): 816.

27. Blau J., Young M.W. Cycling vrille expression is required for a functional Drosophila clock. Cell. 1999. 99(6): 661.

28. Cyran S.A., Buchsbaum A.M., Reddy K.L., Lin M.C., Glossop N.R., Hardin P.E., Young M.W., Storti R.V., Blau J. vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock. Cell. 2003. 112(3): 329.

29. Koh K., Zheng X., Sehgal A. JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS. Science. 2006. 312(5781): 1809.

30. Pittendrigh C.S., Daan S. A functional analysis of circadian pacemakers in nocturnal rodents. V. Pacemaker structure: a clock for all seasons. J. Comp. Physiol. 1976. 106(2): 333.

31. Grima B., Chelot E., Xia R., Rouyer F. Morning and evening peaks of activity rely on different clock neurons of the Drosophila brain. Nature. 2004. 431(7010): 869.

32. Park J.H., Hall J.C. Isolation and chronobiological analysis of a neuropeptide pigment-dispersing factor gene in Drosophila melanogaster. J. Biol. Rhythms. 1998. 13(3): 219.

33. Collins B., Kane E.A., Reeves D.C., Akabas M.H., Blau J. Balance of activity between LN(v)s and glutamatergic dorsal clock neurons promotes robust circadian rhythms in Drosophila. Neuron. 2012. 74(4): 706.

34. Hankins M.W., Peirson S.N., Foster R.G. Melanopsin: an exciting photopigment. Trends Neurosci. 2008. 31(1): 27.

35. Kursky M.D. The role of 5-hydroxytryptamine (serotonin) in bioenergetic processes: Ph.D (Biol.) thesis. Kyiv, 1971. 

36. Serotonin vs melatonin or balance of nature

37. Lowrey P.L., Takahashi J.S. Genetics of the mammalian circadian system: Photic entrainment, circadian pacemaker mechanisms, and posttranslational regulation. Annu. Rev. Genet. 2000. 34: 533.

38. Nohales M.A., Kay S.A. Molecular mechanisms at the core of the plant circadian oscillator. Nat. Struct. Mol. Biol. 2016. 23(12): 1061.

39. Tauber E., Zordan M., Sandrelli F., Pegoraro M., Osterwalder N., Breda C., Daga A., Selmin A., Monger K., Benna C., Rosato E., Kyriacou C.P., Costa R. Natural selection favors a newly derived timeless allele in Drosophila melanogaster. Science. 2007. 316(5833): 1895.

40. Chacolla-Huaringa R., Moreno-Cuevas J., Trevino V., Scott S.P. Entrainment of Breast Cell Lines Results in Rhythmic Fluctuations of MicroRNAs. Int. J. Mol. Sci. 2017. 18(7): E1499.

41. Feng D., Liu T., Sun Z., Bugge A., Mullican S.E., Alenghat T., Liu X.S., Lazar M.A. A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science. 2011. 331(6022): 1315.

42. O’Neill J.S., Reddy A.B. Circadian clocks in human red blood cells. Nature. 2011. 469(7331): 498.

43. Edgar R.S., Green E.W., Zhao Y., van Ooijen G., Olmedo M., Qin X., Xu Y., Pan M., Valekunja U.K., Feeney K.A., Maywood E.S., Hastings M.H., Baliga N.S., Merrow M., Millar A.J., Johnson C.H., Kyriacou C.P., O’Neill J.S., Reddy A.B. Peroxiredoxins are conserved markers of circadian rhythms. Nature. 2012. 485(7399): 459.

44. Sehadova H., Glaser F.T., Gentile C., Simoni A., Giesecke A., Albert J.T., Stanewsky R. Temperature entrainment of Drosophila’s circadian clock involves the gene nocte and signaling from peripheral sensory tissues to the brain. Neuron. 2009. 64(2): 251.

45. Chen C., Buhl E., Xu M., Croset V., Rees J.S., Lilley K.S., Benton R., Hodge J.J., Stanewsky R. Drosophila Ionotropic Receptor 25a mediates circadian clock resetting by temperature. Nature. 2015. 527(7579): 516.

46. Simoni A., Wolfgang W., Topping M.P., Kavlie R.G., Stanewsky R., Albert J.T. A mechanosensory pathway to the Drosophila circadian clock. Science. 2014. 343(6170): 525.

47. Ozturk N., Ozturk D., Kavakli I.H., Okyar A. Molecular Aspects of Circadian Pharmacology and Relevance for Cancer Chronotherapy. Int. J. Mol. Sci. 2017. 18(10): E2168.

48. Toh K.L., Jones C.R., He Y., Eide E.J., Hinz W.A., Virshup D.M., Ptаcek L.J., Fu Y.H. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science. 2001. 291(5506): 1040.

49. Patke A., Murphy P.J., Onat O.E., Krieger A.C., Ozcelik T., Campbell S.S., Young M.W. Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder. Cell. 2017. 169(2): 203.

50. He Y., Jones C.R., Fujiki N., Xu Y., Guo B., Holder J.L. Jr., Rossner M.J., Nishino S., Fu Y.H. The transcriptional repressor DEC2 regulates sleep length in mammals. Science. 2009. 325(5942): 866.

51. Honma S., Kawamoto T., Takagi Y., Fujimoto K., Sato F., Noshiro M., Kato Y., Honma K. Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature. 2002. 419(6909): 841.

52. Goldfarb L.G., Petersen R.B., Tabaton M., Brown P., LeBlanc A.C., Montagna P., Cortelli P., Julien J., Vital C., Pendelbury W.W. Fatal familial insomnia and familial Creutzfeldt-Jakob disease: disease phenotype determined by a DNA polymorphism. Science. 1992. 258(5083): 806.

53. Roenneberg T., Merrow M. The Circadian Clock and Human Health. Curr. Biol. 2016. 26(10): R432.

54. Panda S. Circadian physiology of metabolism. Science. 2016. 354(6315): 1008.

55. Nedeltcheva A.V., Scheer F.A. Metabolic effects of sleep disruption, links to obesity and diabetes. Curr. Opin. Endocrinol. Diabetes Obes. 2014. 21(4): 293.

56. James P., Bertrand K.A., Hart J.E., Schernhammer E.S., Tamimi R.M., Laden F. Outdoor Light at Night and Breast Cancer Incidence in the Nurses’ Health Study II. Environ. Health Perspect. 2017. 125(8): 087010.

57. Huffington A. The Sleep Revolution. Transforming Your Life, One Night at a Time. (Harmony, 2016).

58. Hatori M., Gronfier C., Van Gelder R.N., Bernstein P.S., Carreras J., Panda S., Marks F., Sliney D., Hunt C.E., Hirota T., Furukawa T., Tsubota K. Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies. NPJ Aging Mech. Dis. 2017. (3): 9.

59. Hirota T., Kay S.A. Identification of small-molecule modulators of the circadian clock. Methods Enzymol. 2015. 551: 267.