Visn. Nac. Akad. Nauk Ukr. 2018. (8): 48-57 

A.I. Vovk
Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine, Kyiv

Transcript of scientific report at the meeting of the Presidium of NAS of Ukraine, June 27, 2018

In this report, the results of investigations in the area of bioorganic chemistry which are being carried out in the department of bioorganic mechanisms of Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine are presented. The scientific works were aimed at searching for and designing the potentially bioactive organic substances and included the study of their action mechanisms. Particularly, new possibilities were demonstrated for creation of inhibitors of therapeutically important enzymes, effective antioxidants, and spin probes. New data concerning relationships between the structures and biological actions of organophosphorus and heterocyclic compounds as well as macrocycles and fullerenes were established. The possibilities of using computer modeling for prediction of bioactivity of these compounds were shown. Implications of the obtained results for developing drugs were discussed.

Language of article: ukrainian



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  27. Kobzar O.L., Trush V.V., Tanchuk V.Y., Zhilenkov A.V., Troshin P.A., Vovk A.I. Fullerene derivatives as a new class of inhibitors of protein tyrosine phosphatases. Bioorganic & Medicinal Chemistry Letters. 2014. 24(14): 3175.