Home /Archive /2016 /2016 №1 /2016_1_2

Visn. Nac. Akad. Nauk Ukr. 2016. (1): 11-19
https://doi.org/10.15407/visn2016.01.011

I.A. Akimov, V.A. Kharchenko
Schmalhausen Institute of Zoology of National Academy of Sciences of Ukraine, Kyiv

"NEGLECTED" SCIENCE
Nobel Prize in Physiology and Medicine for 2015

Abstract:
The Nobel Prize winners in Physiology and Medicine for 2015 became parasitologist William Campbell, biochemist Satoshi Omura and biologist Youyou Tu. Half of the prize was awarded for the discovery of avermectin - a new class of medications contributed to combat with river blindness disease (onchocerciasis) and lymphatic filariasis, and also were shown to be effective against other parasitic diseases. The second half of the prize was conferred to a Chinese researcher for the discovery of artemisinin - the medicine that is of great help for patients suffering from malaria. Youyou Tu became the first Nobel Prize winner in Physiology and Medicine from China.
Keywords: "neglected" diseases, onchocerciasis, helminthoides, malaria, Nobel Prize.

 

Language of article: ukrainian

REFERENCES

  1. Sukhdeo M.V. Where are the parasites in food webs. Parasites & Vectors. 2012. 5: 239. http://doi.org/10.1186/1756-3305-5-239
  2. Sukhdeo M.V. Food webs for parasitologists: a review. J. Parasitol. 2010. 96(2): 273. http://doi.org/10.1645/GE-2254.1
  3. World Health Organization. Neglected tropical diseases. http://www.who.int/neglected_diseases/diseases/en/.
  4. Naghavi M., Wang H., Lozano R., Davis A., Liang X., Zhou M., Vollset S.E., Ozgoren A.A., Abdalla S., Abd-Allah F. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015. 385(9963): 117. http://doi.org/10.1016/S0140-6736(14)61682-2
  5. The 2015 Nobel Prize in Physiology or Medicine. Press Release. http://www.nobelprize.org/nobel_prizes/medicine/laureates/2015/press.html. 
  6. Neglected tropical diseases. https://en.wikipedia.org/wiki/Neglected_tropical_diseases#cite_note-1. 
  7. Fenwick A. The global burden of neglected tropical diseases. Public Health. 2012. 126(3): 233. http://dx.doi.org/10.1016/j.puhe.2011.11.015
  8. Neglected diseases fall outside the market. http://www.ft.com/intl/cms/s/0/07bfe8f2-5e05-11e4-bc04-00144feabdc0.html#axzz3MMnaQdHZ. 
  9. Saint André A., Blackwell N.M., Hall L.R., Hoerauf A., Brattig N.W., Volkmann L., Taylor M.J., Ford L., Hise A.G., Lass J.H. The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness. Science. 2002. 295(5561): 1892. http://dx.doi.org/10.1126/science.1068732
  10. World Health Organization. Onchocerciasis. http://www.who.int/mediacentre/factsheets/fs374/en/.  
  11. Onchocerca volvulus. http://en.wikipedia.org/wiki/Onchocerca_volvulus.  
  12. Acharya M. Onchocerciasis. http://www.hxbenefit.com/onchocerciasis.html.  
  13. World Health Organization. Epidemiology. http://www.who.int/lymphatic_filariasis/epidemiology/en/.
  14. World Health Oragnization. Lymphatic filariasis. http://www.who.int/lymphatic_filariasis/en/.  
  15. Salamatin R.V., Pavlikovska T.M., Sagach O.S., Nikolayenko S.M., Kornyushin V.V., Kharchenko V.O., Masny A., Cielecka D., Konieczna-Salamatin J., Conn D.B., Golab E. Human dirofilariasis due to Dirofilaria repens in Ukraine, an emergent zoonosis: epidemiological report of 1465 cases. Acta Parasitol. 2013. 58(4): 592. http://doi.org/10.2478/s11686-013-0187-x
  16. Kharchenko V., Kornyushin V., Varodi E., Malega O. Occurrence of Echinococcus multilocularis (Cestoda, Taeniidae) in red foxes (Vulpes vulpes) from Western Ukraine. Acta Parasitol. 2008. 53(1): 36. http://doi.org/10.2478/s11686-008-0008-9
  17. Geary T.G. Ivermectin 20 years on: maturation of a wonder drug. Trends Parasitol. 2005. 21(11): 530. http://doi.org/10.1016/j.pt.2005.08.014
  18. Borgsteede F., Dvojnos G., Kharchenko V. Benzimidazole resistance in cyathostomes in horses in the Ukraine. Vet. Parasitol. 1997. 68(1): 113. http://doi.org/10.1016/S0304-4017(96)01050-3
  19. Kuzmina T.A., Kharchenko V.O. Anthelmintic resistance in cyathostomins of brood horses in Ukraine and influence of anthelmintic treatments on strongylid community structure. Vet. Parasitol. 2008. 154(3–4): 277. http://doi.org/10.1016/j.vetpar.2008.03.024
  20. Campbell W.C. Ivermectin: an update. Parasitol. Today. 1985. 1(1): 10. http://doi.org/10.1016/0169-4758(85)90100-0
  21. Chaccour C.J., Kobylinski K.C., Bassat Q., Bousema T., Drakeley C., Alonso P., Foy B.D. Ivermectin to reduce malaria transmission: a research agenda for a promising new tool for elimination. Malar. J. 2013. 12: 153. http://doi.org/10.1186/1475-2875-12-153
  22. Thomson Reuters Forecasts Nobel Prize Winners. http://thomsonreuters.com/en/press-releases/2015/september/thomson-reuters-forecasts-nobel-prize-winners.html.
  23. Burg R.W., Miller B.M., Baker E.E., Birnbaum J., Currie S.A., Hartman R., Kong Y.-L., Monaghan R.L., Olson G., Putter I., Tunac J.B., Wallick H., Stapley E.O., Oiwa R., Omura S. Avermectins, new family of potent anthelmintic agents: producing organism and fermentation. Antimicrob. Agents Chemother. 1979. 15(3): 361. http://doi.org/10.1128/AAC.15.3.361
  24. Egerton J., Ostlind D., Blair L., Eary C., Suhayda D., Cifelli S., Riek R., Campbell W. Avermectins, new family of potent anthelmintic agents: efficacy of the B1a component. Antimicrob. Agents Chemother. 1979. 15(3): 372. http://doi.org/10.1128/AAC.15.3.372
  25. Õmura S., Crump A. The life and times of ivermectin – a success story. Nat. Rev. Microbiol. 2004. 2(12): 984. http://.doi.org/10.1038/nrmicro1048
  26. Campbell W.C. Ivermectin and abamectin. (Springer Science & Business Media, 2012).
  27. Campbell W.C. Ivermectin, an antiparasitic agent. Med. Res. Rev. 1993. 13(1): 61. http://doi.org/10.1002/med.2610130103
  28. NRA special review of macrocyclic lactones. (Canberra: National Registration Authority for Agricultural and Veterinary Chemicals, 1998).